Outcomes after Ex-vivo Liver Splitting during Hypothermic Oxygenated Perfusion - A Prospective Case Series
نویسندگان
چکیده
Introduction: Ex-vivo liver graft splitting in donation after brain death increases cold ischemia leading to inferior outcomes compared whole grafts. Hypothermic Oxygenated Perfusion (HOPE) improves of marginal grafts and may also benefit split We present from the first case series ex-vivo during HOPE with subsequent transplantation. Method: In 2020, we developed HOPE-Split, an technique concurrent HOPE. included all conventional splits performed 2018-2020 at our center as comparison cohort. Results: During study period, 6 HOPE-Split procedures resulting 12 successful transplantations pediatric adult recipients. HOPE, both partial were perfused for a mean 125min through single portal cannula until respective recipient hepatectomies completed. standard split, displayed significantly shorter static storage times (542min vs 470min, p =0,02) but comparable total preservation (543min 600min). Despite higher donor risk cohort (Donor Risk Index 1,9 2,16, p=0,29), factor V normalization recipients was splits. No primary non function nor early vascular complications occurred normal values follow-up 4 months. Conclusions: Our preliminary results confirm feasibility suggest improved reduced high-risk Pending validation larger cohort, allow improve increase use
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ژورنال
عنوان ژورنال: Hpb
سال: 2022
ISSN: ['1365-182X', '1477-2574']
DOI: https://doi.org/10.1016/j.hpb.2022.05.063